Bacteria in the gut help fight acne
Inflammation is a common side effect of acne, but scientists have found bacteria in the intestines of mice that may be helping fight it.
The research was published in the journal Nature Communications.
The researchers used a mouse model to test their theory that inflammation is a major cause of acne.
“We want to see if we can use this mouse model as a model to prove that inflammation can actually help fight inflammatory acne,” Professor Robert Bauersma, from the University of Amsterdam, said.
Dr Bauermans research was funded by the Dutch National Science Foundation.
He and his colleagues used a genetically engineered mouse model of inflammatory acne known as FAP3 (Fungal Acne Progenitor 3), which is produced by the Bacteroides group of bacteria.
Scientists have long known that FAP4, which is also produced by Bacteros bacteria, is responsible for the production of inflammation.
In the study, the researchers injected FAP2 into the intestals of FAP1 mice, and observed that FASP2, FAP6 and FAP7 produced inflammatory responses in the mice.
As expected, FASPs3 and 4 produced the same inflammatory responses.
However, F2p4 was able to inhibit FAP-3-producing bacteria in both FAP5 and F6 mice.
This suggests that F2Ps4 and F2P6 have different functions in their intestines, said the study’s lead author, Dr Paul Brouwer.
This is because F2s4 and 5 have a different structure that allows them to enter and remove the FAP cells from the bacteria that produce FAP.
Although the study was small, it suggests that a mouse’s ability to regulate their gut bacteria can influence the way inflammation is induced, said Professor Bauerman.
A similar model was recently shown to be effective in preventing inflammatory acne in mice, Dr Brouer said.
“There are many reasons why this could work,” he said.
“There are also some of the benefits that this study gives us that we are already beginning to use in the clinic.”
Dr Brouewer said there was also a need for a larger-scale study to test whether FAP could be used to treat inflammatory acne.
“The next step is to see whether we can get a large enough sample size and do the same in humans,” he added.
If the results are positive, it would be a significant step towards an effective treatment.
“This study provides a lot of evidence that it could work and is a step towards a drug that we can see in humans in the near future,” Dr Bouwer said.
Professor Bauerts team is now working to investigate whether FASPP4 can be produced in mice and how this might affect inflammation.