Anti-acne drug for acne triggers in mice
This week, a new anti-acnes drug called Proactiv has been shown to activate the immune system in mice, and researchers have been exploring whether this could help treat acne.
The drugs work by preventing the growth of harmful bacteria and fungi, which cause acne to form.
They also have some side effects, including nausea and vomiting.
But a new study published in the journal Nature Chemistry is looking at the effect the drugs might have on the immune systems of mice, where they are used as adjunctive therapies.
The researchers were able to show that the drugs blocked the production of inflammatory molecules and other immune-related molecules, and that this could make them more effective at treating acne.
“When the molecules are destroyed by the immune response, the inflammation in the skin is reduced and less aggressive,” said Dr. Rohan M. Jha, one of the study’s lead authors.
“These molecules then act as a trigger for the immune cells to fight against the bacteria.”
Mice treated with Proactiv had significantly fewer harmful bacteria, as well as fewer skin tumors, and they also showed significantly fewer changes in their skin cell count, which is a measure of the damage that bacteria can do to skin cells.
That’s important because a study published last year showed that acne is caused by a combination of bad bacteria and a combination by bacteria that are harmful to skin.
“The finding that these compounds act on the skin in a specific way could help prevent the growth and progression of acne and may even help to reverse it,” said Jha.
Mice also showed less inflammation in their noses, where the harmful bacteria were produced, and their skin cells showed fewer scars, which can lead to breakouts.
Mice with Proactive also had a significant decrease in the production and release of a type of inflammatory molecule called interleukin-6, a molecule that is produced by some of the skin’s most sensitive cells, the keratinocytes.
“We believe this is important because it means that these drugs could potentially have a similar effect on the keratocyte response as they do on the inflammatory response,” Jha said.
“This may explain why they’re not as effective against skin cancer.”
The study also looked at the effectiveness of Proactiv against the growth, migration, and proliferation of the fungus Candida albicans, a bacterium that can cause severe skin infections.
Proactiv also had some anti-inflammatory effects on keratinocyte growth and migration, which was important for the development of skin cancer.
“These results suggest that these two anti-inflammatories could be helpful in treating acne,” said the study.
It’s not clear yet whether Proactiv would be a good choice for treating acne, but Jha says it is a good start for people who suffer from acne.
A new drug that works in miceCould Proactiv be a new drug?
A group of researchers led by Professor Rajendra Singh of the University of Toronto is looking to create a new class of drugs that are specifically targeted against fungi, such as Candida, and have similar properties to Proactiv.
The team is testing a new antibiotic, called TALA, to treat acne in mice.
TALa has the ability to activate human skin cells to produce anti-fungus antibodies.
There are two drugs that can produce antiFungus antibody antibodies, but they are both very toxic.
TALA is much more selective and has less toxicity than antiF.
Singh says he has been testing the compound to see if it would work against Candida and other fungi that cause acne.
The team has also been studying whether Proact could be used to treat inflammation, which could be a possible next step.
Proactiv could be the next big thing in acne treatmentSource: National Institutes of Health